TB-500 is a synthetic version of the naturally occurring 43-amino acid peptide, Thymosin b4. Specifically, TB-500 is a short-chain fragment (typically the acetylated 17–23 segment: Ac-LKKTETQ) that retains the core regenerative properties of the full protein. In research, it is classified as a powerful G-actin sequestering molecule, fundamental to cellular structure and movement.
Research Focus
Investigators study TB-500 for its potent role in systemic tissue repair and wound modulation. Key research areas include:
- Actin Regulation & Cell Migration: Researching how TB-500 promotes the polymerization of actin, which is essential for cells to physically move to the site of an injury to initiate repair.
- Angiogenesis: Studying the peptide's ability to stimulate the formation of new blood vessels, ensuring nutrient and oxygen delivery to damaged tissues (including tendons and ligaments).
- Tissue Regeneration: Observing its effects on the repair of skeletal muscle, cardiac tissue, and dermal wounds in animal models.
- Anti-Inflammatory Properties: Investigating its capacity to down-regulate inflammatory chemokines and cytokines, thereby reducing secondary tissue damage during the recovery phase.
- Neuroprotection: Emerging studies explore its potential in promoting remyelination and neuronal survival following neurological injury.
Specifications
- Purity: ≥99% (HPLC/MS verified)
- Form: Lyophilized white powder (Acetate salt) in sterile vials
- Molecular Formula: $C_{38}H_{68}N_{10}O_{14}$
- Molecular Weight: 889.01 g/mol
- Storage: Store desiccated at -20°C for long-term stability. After reconstitution, store at 2–8°C; use within a limited window to prevent degradation.
Blood Testing & Side Effects
Research into the biological effects of TB-500 in laboratory subjects often includes monitoring for:
- Side Effects: Documented observations include temporary fatigue, dizziness, or localized irritation at the injection site.
- Blood Monitoring: Researchers typically monitor CBC (Complete Blood Count) and inflammatory markers (such as CRP) to evaluate systemic response to the compound.
Research Disclaimer
For laboratory research only. Not for human consumption, therapeutic use, or any non-research application. This product is intended solely for use by qualified researchers in controlled laboratory settings. TB-500 is strictly prohibited for use by athletes under WADA regulations.