Overview
Hexarelin (Examorelin) is a synthetic hexapeptide growth hormone releasing peptide (GHRP), derived from GHRP-6. It has been modified to enhance its potency and stability. Hexarelin is considered one of the strongest GH releasers in the GHRP family.
Beyond GH secretion, Hexarelin has generated research interest for potential cardioprotective effects independent of its GH-releasing activity, acting through cardiac-specific receptors. This dual action makes it valuable for research applications.
Mechanism of Action
Hexarelin acts primarily through the ghrelin receptor (GHSR-1a) to stimulate GH release. However, it also interacts with cardiac-specific receptors, including CD36, which may mediate its cardiovascular effects independently of GH. This dual mechanism makes Hexarelin unique among GHRPs.
Key Benefits
- Potent GH Secretion
- Cardioprotective Effects
- Anti-fibrotic Properties
- Neuroprotective Potential
Research & Indications
Hexarelin has been researched extensively for its potent growth hormone releasing effects. Studies show it produces robust and sustained GH elevations. It's also being investigated for potential cardioprotective effects, with research indicating it can reduce infarct size and improve left ventricular function.
Preliminary research also suggests Hexarelin possesses anti-fibrotic properties in cardiac tissue and neuroprotective properties through both GH-mediated effects and direct interactions with neural tissue receptors.
Dosing Protocols
Disclaimer: The following dosing information is for research purposes only and does not constitute medical advice. Consult with a qualified healthcare professional before using Hexarelin.
Research has used dosages from 100 mcg to 300 mcg in clinical studies. Due to desensitization concerns, research protocols often include cycling approaches.
| Goal | Dose | Frequency | Route |
|---|---|---|---|
| GH Release | 100-300 mcg | 1-3 times daily | SubQ or IM |
Supplies Needed
For an 8-16 week protocol:
- Peptide Vials: 4-10 vials of 2mg each
- Insulin Syringes (U-100): 50-100 syringes
- Bacteriostatic Water: 2-3 × 10mL bottles
- Alcohol Swabs: One for vial + one for injection site daily
Side Effects & Safety
Potential side effects of Hexarelin may include increased cortisol and prolactin levels, which can lead to related symptoms. Some users have reported flushing, and desensitization can occur with prolonged use, reducing its effectiveness over time. As with any peptide, allergic reactions are possible. It is essential to monitor hormone levels and cycle the peptide to mitigate desensitization.
Storage & Handling
Store lyophilized Hexarelin at -20°C. Reconstitute with bacteriostatic water and use promptly. Keep reconstituted solution refrigerated and protect from light.